Preliminary Study of Novel Bio-Crypto Key Generation Using Clustering-Based Binarization of ECG Features.

In modern society, the popularity of wearable devices has highlighted the need for data security. Bio-crypto keys (bio-keys), especially in the context of wearable devices, are gaining attention as a next-generation security method. Despite the theoretical advantages of bio-keys, implementing such systems poses practical challenges due to their need for flexibility and convenience. Electrocardiograms (ECGs) have emerged as a potential solution to these issues but face hurdles due to intra-individual variability. This study aims to evaluate the possibility of a stable, flexible, and convenient-to-use bio-key using ECGs. We propose an approach that minimizes biosignal variability using normalization, clustering-based binarization, and the fuzzy extractor, enabling the generation of personalized seeds and offering ease of use. The proposed method achieved a maximum entropy of 0.99 and an authentication accuracy of 95%. This study evaluated various parameter combinations for generating effective bio-keys for personal authentication and proposed the optimal combination. Our research holds potential for security technologies applicable to wearable devices and healthcare systems.

ECG Authentication Based on Non-Linear Normalization under Various Physiological Conditions.

The development and use of wearable devices require high levels of security and have sparked interest in biometric authentication research. Among the available approaches, electrocardiogram (ECG) technology is attracting attention because of its strengths in spoofing. However, morphological changes of ECG, which are affected by physical and psychological factors, can make authentication difficult. In this paper, we propose authentication using non-linear normalization of ECG beats that is robust to changes in ECG waveforms according to heart rate fluctuations in various daily activities. We performed a non-linear normalization method through the analysis of ECG alongside heart rate, evaluating similarities and authenticating the performance of our new method compared to existing methods. Compared with beats before normalization, the average similarity of the proposed method increased 23.7% in the resting state and 43% in the non-resting state. After learning in the resting state, authentication performance reached 99.05% accuracy for the resting state and 88.14% for the non-resting state. The proposed method can be applicable to an ECG-based authentication system under various physiological conditions.

Design and synthesis of novel antidiabetic agents.

The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARgamma) are reported. The PPARgamma agonistic activity of the most potent compound in this series is comparable to that of the thiazolidinedione-based antidiabetic drugs currently in clinical use.